Home FOR AUTHORS Neoplasma 2009 Neoplasma Vol.56, No.2, p.130-135, 2009

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Neoplasma Vol.56, No.2, p.130-135, 2009

Title: Expression pattern of anti-apoptotic protein survivin in dysplastic nevi
Author: M. Adamkov, L. Lauko, S. Balentova, J. Pec, M. Pec, J. Rajcani

Abstract: The anti-apoptotic protein survivin was detected in a panel of 27 dysplastic nevi. From each representative paraffin block 4 mm sections were cut and stained with anti-survivin antibody (DAKO, Clone 12C4). In each section, the labeling intensity, the subcellular location of survivin antigen, the percentage of labeled cells and the degree of dysplasia were assessed. Survivin was present in 23 out of 27 cases (85.2%), but absent in 4/27 cases (14.8%). Positive staining was confined to the cytoplasm (C) of nevus cells only in 18 cases (66.7%), while cytoplasmic as well as nuclear positivity (NC) was found in 5 cases (18.5%). In no case solely nuclear staining could be seen. Furthermore, in 4 out of 5 cases (80%) with NC staining, severe dysplasia was found. Our data point at usefulness of survivin staining, otherwise rarely performed in dysplastic nevi. We confirm the importance of nuclear location of the survivin antigen, which may be helpful for assessing the possible progression to melanoma.

Keywords: survivin, immunohistochemistry, nevi, dysplasia, melanoma
Year: 2009, Volume: 56, Issue: 2 Page From: 130, Page To: 135
doi:10.4149/neo_2009_02_130
Price: 14.40 €






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