Home Acta Virologica 2009 Acta Virologica Vol.53, No.1, p.07-13, 2009

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.53, No.1, p.07-13, 2009

Title: Reduced expression of angiopoietin-1 in Hantaan virus-infected human umbilical vein endothelial cell increases their permeability
Author: J. Y. Hwang, J. W. Park, S. Y. Hong, H. S. Park

Abstract: Hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus (HTNV) is characterized by vascular hemorrhage and acute renal failure. Angiopoietin-1 (Ang-1) is a glycoprotein that maintains vessel integrity and reduces endothelial permeability. We found that in HTNV-infected human umbilical vein endothelial cells (HUVECs) the levels of Ang-1 mRNA and protein were reduced on days 2 and 3 post-infection (p.i.), when endothelial permeability was increased. The HTNV-stimulated permeability was reduced by treatment of HUVECs with Ang-1. The plasma Ang-1 level was lower in HFRS patients than in healthy persons. Paired plasma samples of HFRS patients revealed markedly lower Ang-1 levels during the acute phase of HFRS as compared to the convalescent phase. These findings suggested that HTNV reduced the Ang-1 expression in endothelial cells that might play an important role in the increase of vascular permeability in HFRS.

Keywords: Hantaan virus; angiopoietin-1; vascular permeability; hemorrhagic fever with renal syndrome
Year: 2009, Volume: 53, Issue: 1 Page From: 7, Page To: 13
doi:10.4149/av_2009_01_07
Price: 16.80 €






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