Home Endocrine Regulations 2009 Endocrine Regulations Vol.43, No.2, p.59-64, 2009

Journal info

Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Endocrine Regulations Vol.43, No.2, p.59-64, 2009

Title: ANIMAL MODEL OF METASTATIC PHEOCHROMOCYTOMA: EVALUATION BY MRI AND PET
Author: L. Martiniova, E. W. Lai, D. Thomasson, D.O. Kiesewetter, J. Seidel, M. J. Merino, R. Kvetnansky, K. Pacak

Abstract: Objective. The development of metastatic pheochromocytoma animal model provides a unique opportunity to study the physiology of these rare tumors and to evaluate experimental treatments. Here, we describe the use of small animal imaging techniques to detect, localize and characterize metastatic lesions in nude mice.

Methods. Small animal positron emission tomography (PET) imaging and magnetic resonance imaging (MRI) were used to detect metastatic lesions in nude mice following intravenous injection of mouse pheochromocytoma cells. [18F]-6-fluoro-dopamine ([18F]-DA) and [18F]-L-6-fluoro-3,4-dihydroxyphenylalanine, which are commonly used for localization of pheochromocytoma lesions in clinical practice, were selected as radiotracers to monitor metastatic lesions by PET.

Results. MRI was able to detect liver lesions as small as 0.5mm in diameter. Small animal PET imaging using [18F]-DA and [18F]-DOPA detected liver, adrenal gland, and ovarian lesions.

Conclusion. We conclude that MRI is a valuable technique for tumor growth monitoring from very early to late stages of tumor progression and that animal PET confirmed localization of metastatic pheochromocytoma in liver with both radiotracers.



Keywords: Anatomical imaging – Functional imaging – MRI, small animal PET – Animal model
Year: 2009, Volume: 43, Issue: 2 Page From: 59, Page To: 64
doi:10.4149/endo_2009_02_59


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.