General Physiology and Biophysics Vol.28, No.1, p.56-62, 200

General Physiology and Biophysics Vol.28, No.1, p.56-62, 2009

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.28, No.1, p.56-62, 2009
Title: Comparison of in vitro chondrogenic potential of human mesenchymal stem cells derived from bone marrow and adipose tissue
Author: Lubos Danisovic, Ivan Varga, Stefan Polak, Marcela Ulicna, Livia Hlavackova, Daniel Böhmer, Jan Vojtassak

Abstract: In the present work, the human bone marrow and adipose tissue-derived mesenchymal stem cells (MSCs) were isolated and expanded under in vitro condition. After their phenotypic analysis, the chondrogenic differentiation was induced by using of the three-dimensional culture system without supplementation of growth factors, and their chondrogenic potential was compared. Obtained results proved that both types of MSCs undergo the process of chondrogenic differentiation. Comparative analysis showed that chondrogenic potential of adipose tissue-derived MSCs was slightly decreased in comparison with bone marrow-derived MSCs. However, both evaluated MSCs may play important role in the cartilage tissue engineering.

Keywords: Chondrogenic potential — Mesenchymal stem cells — Bone marrow — Adipose tissue — In vitro study

Year: 2009, Volume: 28, Issue: 1	Page From: 56, Page To: 62
doi:10.4149/gpb_2009_01_56
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