Home HOME General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.1, p.70-77, 2009

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.28, No.1, p.70-77, 2009

Title: Photodynamic activity of pyropheophorbide methyl ester and pyropheophorbide a in dimethylformamide solution
Author: Saleh Al-Omari, Ahmad Ali

Abstract: Comparative spectroscopic study including the photosensitizers of pyropheophorbide methyl ester (PPME) and pyropheophorbide a (PPa) was performed to study their photodynamic activity. The investigated photosensitizers in a homogeneous system of dimethylformamide (DMF) are not photostable upon irradiation. The photobleaching efficiency of PPa is higher than that of PPME. Combining these results with the data obtained by measuring the singlet oxygen quantum yield and the hydroxyl group generation, it was revealed that the photobleaching efficiency could be correlated with the singlet oxygen quantum yield and the hydroxyl group production of the photosensitizer.

Keywords: Tumor — Singlet molecular oxygen — Free radicals — PPME — Fluorescence — Photobleaching — Absorption
Year: 2009, Volume: 28, Issue: 1 Page From: 70, Page To: 77
doi:10.4149/gpb_2009_01_70


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