Home General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.1, p.94-97, 2009

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.28, No.1, p.94-97, 2009

Title: Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein
Author: Verica Lj. Milosević, Vladimir Z. Ajdzanović, Branka T. Sosić-Jurjević, Branko R. Filipović, Marjana P. Brkić, Natasa M. Nestorović, Milka I. Sekulić

Abstract: The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases. The aim of this study was to examine the morphofunctional characteristics of adrenocorticotrophic (ACTH) cells and blood concentrations of ACTH in sham-operated, orchidectomized and genistein-treated orchidectomized, 16-month-old Wistar male rats. Genistein (10 mg/kg/day) was administered subcutaneously for three weeks, while the control groups received the vehicle alone. Orchidectomy and genistein treatment decreased the volume density of ACTH cells and reduced (p < 0.05) circulating ACTH concentrations in comparison with control groups. In conclusion, genistein modulated the morphofunctional features of ACTH cells and decreased blood ACTH levels.

Keywords: ACTH — Genistein — Middle-age — Orchidectomy — Rats
Year: 2009, Volume: 28, Issue: 1 Page From: 94, Page To: 97

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