Home Neoplasma 2009 Neoplasma Vol.56, No.4, p.321-330, 2009

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.56, No.4, p.321-330, 2009

Title: The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol
Author: R. MEZENCEV, P. KUTSCHY, A. SALAYOVA, T. UPDEGROVE, J. F. McDONALD

Abstract: Nitrogen mustards cis-1-methoxy-2-deoxy-2-[N,N-bis(2´-chloroethyl)amino]spirobrassinol (4) and trans-1-methoxy-2-deoxy-2-[N,N-bis(2´-chloroethyl)amino]spirobrassinol (5) derived from 1-methoxyspirobrassinol, an indole phytoalexin produced by the Japanese radish Raphanus sativus var. hortensis were designed as prospective dual-action compounds with DNA-alkylating effect and glutathione-depleting effects that may sensitize cancer cells to alkylating agents. Both new compounds demonstrated cytostatic/cytotoxic effects on various leukemia and ovarian cancer cell lines and dsDNA-destabilizing effects in vitro. Compound 4, the more promising of the two compounds, exerts earlier onset of anticancer effects on Jurkat cells via induction of apoptosis compared to the traditional alkylating anticancer agent melphalan. In addition, it demonstrated higher potency on ovarian cancer OVCAR-3 cell line and lower fold resistance between Jurkat and Jurkat-M cells selected for the resistance to melphalan. Therefore, compound 4 may be less affected by certain cancer drug resistance mechanisms than melphalan and it may become a prototype of a new class of anticancer active nitrogen mustards that combine DNA-damaging and DNA-damage-sensitizing properties.

Keywords: nitrogen mustard, indole phytoalexin, methoxyspirobrassinol, DNA-damaging compounds, drug resistance
Year: 2009, Volume: 56, Issue: 4 Page From: 321, Page To: 330
doi:10.4149/neo_2009_04_321


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