Home CONTACT Neoplasma 2009 Neoplasma Vol.56, No.4, p.357-360, 2009

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.56, No.4, p.357-360, 2009

Title: HSP27 diagnostic utility in the fine needle aspirate of breast. Correlation with progesterone and estrogen receptors
Author: J. MLYNARCZYK-LISZKA, B. MAKSYMIUK, D. PONIKIEWSKA, S. KRZYZOWSKA-GRUCA, D. LANGE, Z. KRAWCZYK, E. MALUSECKA

Abstract: Fine needle aspiration (FNA) is routine diagnostic tool in breast tumors assessment. In some cases, however, limitations of this method do not permit an unequivocal diagnosis. In these, suspected, cases immunocytochemical evaluation of selected biological markers may be of help. The aim of the study was assessment of HSP27 value in diagnosis and discrimination of benign and malignant breast lesions. HSP27 expression was examined by immunocytochemistry in fine needle aspiration smears assessed to C2-C5 categories. In C5 subgroup HSP27 expression was correlated with ER, PR content. Statistically significant differences in HSP27 expression between subsets C2/C5 and C3/C5 were found (p=0.028 and p=0,04, respectively); the differences between C3/C4 categories were not significant. Expression of HSP27 protein in FNA smears can be additional factor, which helps to differentiate benign, and malignant breast lesions, however it is not useful for discrimination of cytological, suspicious lesions.

Keywords: breast cancer, cytology, HSP27, fine needle aspiration
Year: 2009, Volume: 56, Issue: 4 Page From: 357, Page To: 360
doi:10.4149/neo_2009_04_357
Price: 9.60 €






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