Home Acta Virologica 2009 Acta Virologica Vol.53, No.2, p.73-82, 2009

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ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.53, No.2, p.73-82, 2009

Title: Hepatitis B virus infection in non-human primates
Author: P. Sa-nguanmoo, P. Rianthavorn, S. Amornsawadwattana, Y. Poovorawan
Abstract: Hepatitis B viruses (HBVs) represent a serious public health problem affecting 350 to 400 million HBV carriers worldwide. The virus does not exclusively infect humans, but can also be found in non-human primates as in the families Hominidae (chimpanzee, gorilla, orangutan) and Hylobatidae (gibbon), which are distributed over Africa (chimpanzee and gorilla) and Southeast Asia (orangutan and gibbon), the endemic areas of human HBV. The prevalence of asymptomatic HBV carriers reaches in gibbons 23–33% and in orangutans 15%. The genome organization of non-human primate HBVs is nearly identical to that of human HBVs. Because of this close similarity, the question of cross-transmission of HBV between species has arisen. There are many data on cross-transmission of human HBVs to the non-human primates. However, a cross-transmission of HBVs from non-human primates to humans has not been reported yet. Using more advanced diagnostic methods, the non-human primates have increasingly been identified as a reservoir of several viruses such as lymphocryptoviruses, Cercopithecine herpesvirus 1 (CeHV-1), Simian immunodeficiency virus (SIV), Simian foamy virus (SFV), and HBVs. Thus veterinarians, zookeepers, or people in close contact with non-human primates may potentially become infected with those viruses causing severe diseases. Enhanced awareness of prevalence, genetic relatedness and evolution of non-human primate HBVs will help prevent further spread and cross-transmission of these viruses between humans and non-human primates.
Keywords: Hepatitis B virus; humans; non-human primates; prevalence; transmission; evolution
Year: 2009, Volume: 53, Issue: 2 Page From: 73, Page To: 82
doi:10.4149/av_2009_02_73
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