Acta Virologica Vol.53, No.2, p.83-88, 2009

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Founded: 1957
ISSN 0001-723X
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Acta Virologica Vol.53, No.2, p.83-88, 2009
Title: Sindbis virus replicon-based DNA vaccine encoding Rabies virus glycoprotein elicits specific humoral and cellular immune response in dogs
Author: P. K. Gupta, S. S. Dahiya, P. Kumar, A. Rai, C. L. Patel, A. A. Sonwane, M. Saini

Abstract: A Sindbis virus (SINV) replicon-based DNA vaccine encoding Rabies virus (RABV) glycoprotein G developed previously (Saxena et al., Vaccine 26, 6592, 2008) was used for immunization of dogs against rabies. The intradermal injection of DNA vaccine into external ear generated protective level of virus neutralizing antibodies. The cellular immune response was specific to RABV, in particular by an increase in CD3⁺CD4⁺ and CD3⁺CD8⁺ lymphocytes. This study has demonstrated that the SINV replicon-based DNA vaccine encoding RABV G is capable of inducing the protective level of specific immune response in dogs.

Keywords: Rabies virus; glycoprotein; DNA vaccine; dogs; immune response

Year: 2009, Volume: 53, Issue: 2	Page From: 83, Page To: 88
doi:10.4149/av_2009_02_83
Price: 14.40 €

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