Acta Virologica Vol.53, No.2, p.125-129, 2009

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.53, No.2, p.125-129, 2009
Title: Establishment of mouse erythroleukemia cell lines expressing complete Influenza C virus CM2 protein or chimeric protein consisting of CM2 and Influenza A virus M2
Author: Y. Muraki, A. Hay

Abstract: The role of the Influenza C virus (ICV) CM2 protein in virus replication as well as its precise function as an ion channel remains to be elucidated. For this purpose, we established a CM2-expressing mouse erythroleukemia (MEL) cell line and determined the biochemical characteristics of the expressed CM2. The features of the expressed CM2 were similar to those of the viral CM2 synthesized in ICV-infected cells. Furthermore, we established MEL cell line expressing a chimeric protein consisting of characteristic regions of CM2 and Influenza A virus (IAV) M2 protein that could be helpful in elucidation of the specific ion conductance properties.

Keywords: Influenza C virus; Influenza A virus; CM2 protein; chimeric protein; MEL cells

Year: 2009, Volume: 53, Issue: 2	Page From: 125, Page To: 129
doi:10.4149/av_2009_02_125
Price: 12.00 €

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