Home Acta Virologica 2009 Acta Virologica Vol.53, No.2, p.135-138, 2009

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.53, No.2, p.135-138, 2009

Title: Amantadine-resistant influenza A (H3N2) viruses in Iran
Author: J. Yavarian, T. Mokhtari_Azad, N. Z. Shafiei_Jandaghi, R. Nategh

Abstract: Adamantanes have been used for the prophylaxis and treatment of Influenza A virus (IAV) infections worldwide. However, they have limited use because of increasing number of resistant viruses during recent years. In investigating the frequency of amantadine-resistant IAVs (H3N2) circulating in Iran in 2005–2008, we found that M2 sequences of recently circulating viruses that were amantadine-resistant contained a Ser31Asn mutation. Thus, adamantanes should not be used for treatment or prophylaxis of recent IAVs (H3N2) infections. In future, their potential use will depend on the resistance of circulating viruses.

Keywords: Influenza A (H3N2) virus; amantadine; resistance; Iranian isolates
Year: 2009, Volume: 53, Issue: 2 Page From: 135, Page To: 138
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