Acta Virologica Vol.53, No.2, p.135-138, 2009

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Acta Virologica Vol.53, No.2, p.135-138, 2009
Title: Amantadine-resistant influenza A (H3N2) viruses in Iran
Author: J. Yavarian, T. Mokhtari_Azad, N. Z. Shafiei_Jandaghi, R. Nategh

Abstract: Adamantanes have been used for the prophylaxis and treatment of Influenza A virus (IAV) infections worldwide. However, they have limited use because of increasing number of resistant viruses during recent years. In investigating the frequency of amantadine-resistant IAVs (H3N2) circulating in Iran in 2005–2008, we found that M2 sequences of recently circulating viruses that were amantadine-resistant contained a Ser31Asn mutation. Thus, adamantanes should not be used for treatment or prophylaxis of recent IAVs (H3N2) infections. In future, their potential use will depend on the resistance of circulating viruses.

Keywords: Influenza A (H3N2) virus; amantadine; resistance; Iranian isolates

Year: 2009, Volume: 53, Issue: 2	Page From: 135, Page To: 138
doi:10.4149/av_2009_02_135
Price: 9.60 €

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