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Acta Virologica Vol.53, No.2, p.135-138, 2009 |
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Title: Amantadine-resistant influenza A (H3N2) viruses in Iran | ||
Author: J. Yavarian, T. Mokhtari_Azad, N. Z. Shafiei_Jandaghi, R. Nategh | ||
Abstract: Adamantanes have been used for the prophylaxis and treatment of Influenza A virus (IAV) infections worldwide. However, they have limited use because of increasing number of resistant viruses during recent years. In investigating the frequency of amantadine-resistant IAVs (H3N2) circulating in Iran in 2005–2008, we found that M2 sequences of recently circulating viruses that were amantadine-resistant contained a Ser31Asn mutation. Thus, adamantanes should not be used for treatment or prophylaxis of recent IAVs (H3N2) infections. In future, their potential use will depend on the resistance of circulating viruses. |
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Keywords: Influenza A (H3N2) virus; amantadine; resistance; Iranian isolates | ||
Year: 2009, Volume: 53, Issue: 2 | Page From: 135, Page To: 138 | |
doi:10.4149/av_2009_02_135 |
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