Home General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.2, p.126–139, 2009

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.28, No.2, p.126–139, 2009

Title: Effects of cholesterol and unsaturated DOPC lipid on chain packing of saturated gel-phase DPPC bilayers
Author: Thalia T. Mills, Juyang Huang, Gerald W. Feigenson, John F. Nagle

Abstract: Wide angle x-ray scattering (WAXS) from oriented lipid multilayers was used to study the effect of adding cholesterol (Chol) or 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) to gel-phase 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers. Small quantities (X row WAXS peak, and liquid disordered phase, characterized by wide, diffuse WAXS scattering. In contrast, two WAXS peaks indicative of two coexisting phases were not observed in Chol/DPPC mixtures (XChol = 0.07 to 0.40). Instead, Chol caused a gradual increase in the width of the WAXS peak, consistent with a gradual change from a more gel-like to a more liquid-like state rather than passing through a region of two phase coexistence. Our WAXS data include a huge amount of information. A new method of analysis suggests that WAXS data may provide definitive results relating to the disagreements between previously published phase diagrams for Chol/DPPC.

Keywords: Cholesterol — Liquid ordered — Lipid bilayers — Chain packing — Phase diagram
Year: 2009, Volume: 28, Issue: 2 Page From: 126, Page To: 139

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