Home FOR AUTHORS General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.2, p.160–167, 2009

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.28, No.2, p.160–167, 2009

Title: Hydrodynamic size of DNA/cationic gemini surfactant complex as a function of surfactant structure
Author: Ferdinand Devinsky, Martin Pisarcik, Ivan Lacko

Abstract:  The present study deals with the determination of hydrodynamic size of DNA/cationic gemini surfactant complex in sodium bromide solution using the dynamic light scattering method. Cationic gemini surfactants with polymethylene spacer of variable length were used for the interaction with DNA. The scattering experiments were performed at constant DNA and sodium bromide concentrations and variable surfactant concentration in the premicellar and micellar regions as a function of surfactant spacer length. It was found that the DNA conformation strongly depends on the polymethylene spacer length as well as on the surfactant concentration relative to the surfactant critical micelle concentration. Gemini surfactant molecules with 4 methylene groups in the spacer were found to be the least efficient DNA compacting agent in the region above the surfactant cmc. Gemini molecules with the shortest spacer length (2 methylene groups) and the longest spacer length (8 methylene groups) investigated showed the most efficient DNA compaction ability.

Keywords: Gemini surfactant — DNA — Hydrodynamic diameter — Micelle — Surfactant spacer
Year: 2009, Volume: 28, Issue: 2 Page From: 160, Page To: 167

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