Home General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.2, p.190-194, 2009

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.28, No.2, p.190-194, 2009

Title: H2S and HS– donor NaHS inhibits intracellular chloride channels
Author: Lubica Malekova, Olga Krizanova, Karol Ondrias

Abstract: We have characterized the effect of H2S on single channel properties of the chloride channels derived from the rat heart lysosomal vesicles incorporated into a bilayer lipid membrane. The single chloride channel currents were measured in 250 : 50 mmol/l KCl cis/trans solutions. H2S inhibited the chloride channels by decreasing the channel open probability in a concentration-dependent manner. The inhibitory effect of H2S was side-dependent with the IC50 values of 42 and 75 μmol/l for the trans and the cis sides, respectively. The mixture of H2S with the NO donor S-nitroso-N-acetyl-DL-penicillamine had smaller effect (IC50 = 180 μmol/l) than H2S alone. We assume that the inhibitory effect of H2S on chloride channels may be responsible for some of its numerous biological effects.

Keywords: Chloride channels — H2S — Bilayer lipid membrane — Single channel properties — Heart
Year: 2009, Volume: 28, Issue: 2 Page From: 190, Page To: 194

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