Home CONTACT Neoplasma 2009 Neoplasma Vol.56, No.5, p.422-427, 2009

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.56, No.5, p.422-427, 2009

Title: Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population
Author: T. Matakova, M. Sivonova, E. Halasova, D. Mistuna, A. Dzian, J. Masar, D. Dobrota

Abstract: The aim of present study was to summarize the results of a case-control study focused on genetic polymorphisms of selected Phase II metabolizing enzymes (GSTM1, T1, P1) and to investigate the association of these polymorphisms with the colorectal cancer risk among the Slovak population.
A case-control study with 183 colorectal cancer cases and 422 controls was conducted. DNA was extracted from peripheral blood leukocytes, and the polymorphisms of GSTM1, GSTT1 and GSTP1 enzymes were determined by PCR-based methods. Association between specific genotypes and the development of colorectal cancer were examined using logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CI).
The GSTP1 val/val genotype (OR=2.1, 95%CI: 1.1 - 4.0, χ2 = 0.28 and P = 0.0025) was associated with an elevated risk. The statistically significant correlation was found also for the combined genotypes of GSTM1 null and GSTP1 valine homozygosity (OR = 2.7, 95% CI: 1.1–6.1, χ2 = 4.5 and P = 0.03).
The genotype of certain metabolising enzymes affects the risk for colorectal cancer. This effect is also important when certain allelic combinations are studied. In the near future, individual risk assessment may be reached by further increasing the number of studies of polymorphisms, combining them with the traditional epidemiological risk factor.

Keywords: colorectal cancer; Glutathione S-transferase T1, M1, P1; polymorphism
Year: 2009, Volume: 56, Issue: 5 Page From: 422, Page To: 427
doi:10.4149/neo_2009_05_422
Price: 14.40 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.