Home Neoplasma 2009 Neoplasma Vol.56, No.5, p.441-447, 2009

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.56, No.5, p.441-447, 2009

Title: Associations between hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms and risk of developing breast cancer
Author: R. NAIDU, Y. C. HAR, N. A. TAIB

Abstract: The C1772T, G1790A and C111A polymorphisms of Hypoxia-inducible factor-1α (HIF-1α) gene were analyzed in a hospital-based Malaysian population using PCR-RFLP method. Genomic DNA was extracted from the blood samples collected from 410 breast cancer patients and 275 normal and healthy women. We investigated the association between HIF-1α polymorphisms and breast cancer risk, and clinico-pathological parameters in the population. The genotype and allele frequencies of C1772T (P=0.0093 vs P=0.0024) polymorphism were significantly different between the breast cancer cases and normal subjects but similar association was not observed for G1790A (P>0.05) and C111A (P>0.05) polymorphisms, respectively. Women who were CT heterozygotes (OR=1.51; 95% CI, 1.01-2.25), TT homozygotes (OR=4.03; 95% CI, 1.09-17.60) and carriers of T allele genotype (OR=1.65; 95% CI, 1.13-2.43) were significantly associated with increased risk of breast cancer. Significant relationship was observed also between T allele and breast cancer risk (OR=1.69; 95% CI, 1.20-2.40). Clinico-pathological analysis showed that 1772T allele genotype was significantly associated with nodal metastases (P=0.0478) but independent of ER status, tumor grade and patients’ age (P>0.05). Our observations suggest that the polymorphic allele of C1772T may be associated with increased risk of developing breast cancer, and presence of 1772T allele may be a useful genetic marker for tumor prognosis.

Keywords: Hypoxia-inducible factor-1α, genetic polymorphism, breast cancer
Year: 2009, Volume: 56, Issue: 5 Page From: 441, Page To: 447

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