Home Neoplasma 2009 Neoplasma Vol.56, No.6, p.514-520, 2009

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.56, No.6, p.514-520, 2009

Title: Activation of HLA-G expression by 5-aza-2´- deoxycytidine in malignant hematopoetic cells isolated from leukemia patients
Author: K. POLAKOVA, E. BANDZUCHOVA, F. A. SABTY, M. MISTRIK, L. DEMITROVICOVA, G. RUSS

Abstract: Human leukocyte antigen – G (HLA-G) is a non-classical HLA class I antigen with restricted distribution in normal tissues. Ectopic HLA-G expression observed at some pathological circumstances as malignant transformation might be triggered by epigenetic modifications such as DNA demethylation. Recently it was demonstrated that DNA methyltransferase inhibitor 5-aza-2´- deoxycytidine (AdC) induces/enhances HLA-G transcription in many leukemia cell lines of different origin. Here we investigated the effect of AdC on HLA-G expression in malignant hematopoetic cells isolated from patients with acute myeloid leukemia (AML) and chronic lymphocytic leukemia (B-CLL). We detected HLA-G expression in untreated cells from some patients. Nevertheless treatment with 5-aza-2´- deoxycytidine enhanced HLA-G transcription and concomitantly HLA-G protein synthesis in some leukemia cells.

Keywords: HLA-G, DNA demethylation, 5-aza-2´- deoxycytidine, AML, B-CLL
Year: 2009, Volume: 56, Issue: 6 Page From: 514, Page To: 520
doi:10.4149/neo_2009_06_514
Price: 16.80 €






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