Home FOR AUTHORS Neoplasma 2009 Neoplasma Vol.56, No.6, p.526-532, 2009

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Neoplasma Vol.56, No.6, p.526-532, 2009

Title: Phenotype of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance
Author: L. KOVAROVA, I. BURESOVA, T. BUCHLER, R. SUSKA, L. POUR, L. ZAHRADOVA, M. PENKA, R. HAJEK

Abstract: Flow cytometry is a useful tool for the analysis of plasma cells in monoclonal gammopathies. The aim of this study was to find possibilities and limits of multicolour flow cytometry in diagnostics of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) and to identify parameters that could be used to differentiate between these two disorders. Surface markers CD38 and CD138 were used for identification of plasma cells, CD19 and CD56 further distinguished normal and abnormal plasma cells, respectively. The percentage of circulating plasma cells in peripheral blood was lower in MGUS patients then in MM (p

Keywords: plasma cells, multiple myeloma, monoclonal gammopathy, flow cytometry
Year: 2009, Volume: 56, Issue: 6 Page From: 526, Page To: 532
doi:10.4149/neo_2009_06_526
Price: 16.80 €






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