Home CONTACT Neoplasma 2010 Neoplasma Vol.57, No.1, p.20-28, 2010

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.57, No.1, p.20-28, 2010

Title: Comparative study of the immunohistochemical expression of metalloproteinases 2, 7 and 9 between clearly invasive carcinomas and “in situ” trophoblast invasion

Abstract: Matrix metalloproteinases (MMPs) are endopeptidases considered to participate in the transient invasive property of trophoblastic cells during embryo implantation and placentation. The same molecules play an important role in the invasive and metastatic potential of cancer cells. The aim of this study was to compare the immunohistochemical expression of MMP2, 7 and 9 between clearly invasive carcinomas and “in situ” trophoblast invasion in an effort to illuminate their distinct roles in uncontrolled and controlled invasion.
We performed an immunohistochemical analysis of 45 clearly invasive carcinomas of various organs (colorectal, gastric, breast, pulmonary, renal) and 40 first trimester gestation specimens (before the 9th week of gestation). The markers expression was evaluated semiquantitavely, seperately in cancer parenchymal and gestational trophoblastic cells as well as cancer stromal and decidual cells, according to a percentage scale (0 %, 50% of cells) and according to staining intensity (0, +, ++, +++).
MMP9 was expressed more often in the malignant parenchymal as well as in the malignant stromal component of carcinomas than in the trophoblastic (p=0, 0118) and decidual (p=0,017) component of gestations respectively. Although all carcinomas and almost all gestation specimens stained for MMP2 and MMP7, the immunostaining for both molecules was statistically more extensive and intense in trophoblasts and decidual cells by comparison to cancerous elements.
In conclusion, although there seems to be a direct link between cancer invasion and MMP9 immunohistochemical expression, the role of MMP2 and MMP7 appears to be more complicated underlining the complexity of the mechanisms involved in cancer spreading.

Year: 2010, Volume: 57, Issue: 1 Page From: 20, Page To: 28
Price: 21.60 €

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