Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma 2025 Ahead of print 2024 2023 2022 2021 2020 2019 2018 2016 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudba 2025Webshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.57, No.1, p.62-67, 2010 |
||
Title: Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma | ||
Author: W. C. GUO, S. H. ZHAO, L. YU, J. TANG, G. X. WU, J. L. CHEN | ||
Abstract: The aim of the study was to observe the expression of heat shock protein gp96 (HSPgp96) and explore its clinical significance in human osteosarcoma. The expression of HSPgp96 was studied in 44 osteosarcoma tissues including 24 osteoblastic sarcoma and 20 chondroblastic sarcoma, normal tissues adjacent to the sarcomas were evaluated simultaneously. The immunoreactivity was found positive in all osteosarcoma tissues (44/44), but 21.5% (9/44) in normal tissues. HSPgp96 was mainly expressed in cytoplasm of osteoblastic sarcoma, while in nucleus of chondroblastic sarcoma. HSPgp96 immunolabelling had significantly correlation with the Price degree (P 0.05), and histological subtypes (P > 0.05). The HSPgp96 is highly expressed in osteosarcoma and has different immunolocalization during two subtypes of osteosarcoma. The immunopositivity is significantly higher in tumors with lower differentiation. The research implies that HSPgp96 may play a contributive role on the pathogenesis and development in human osteosarcoma, and there is hope in its application in determining the degree of malignancy of cancer and utilization as a target for tumor immunity. |
||
Keywords: heat shock protein gp96, immunoreactivity, osteoblastic sarcoma, chondroblastic sarcoma. | ||
Year: 2010, Volume: 57, Issue: 1 | Page From: 62, Page To: 67 | |
doi:10.4149/neo_2010_01_062 |
||
|
![]() |
|