Home CUSTOMERS Acta Virologica 2009 Acta Virologica Vol.53, No.4, p.233-240, 2009

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.53, No.4, p.233-240, 2009

Title: Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice
Author: Y. Hama, M. Kurokawa, M. Imakita, Y. Yoshida, T. Shimizu, W. Watanabe, K. Shiraki

Abstract: We have reported previously that an increase in interleukin 12 (IL-12) production in the lungs of mice infected with Influenza A virus or an intranasal (i.n.) administration of IL-12 to the infected mice alleviated pneumonia (Tsurita et al., J. Pharmacol. Exp. Therapeut. 298, 362–368, 2001). In this study, we found that in the bronchoalveolar lavage fluids (BALF) obtained from mice infected i.n. with Influenza A virus IL-12 was elevated on day 1 post infection (p.i.) and was followed by tumor necrosis factor alfa (TNF-alfa), IL-18, and interferons alfa, beta, and gama (IFN-alfa, -beta, and -gama) on day 2 p.i. Histochemical analyses of the infected lungs on day 1 p.i. showed the presence of IL-12 and IL-12 mRNA in mononuclear and macrophage-like cells and co-localization of macrophages with viral antigen, while other cytokines were absent. Thus, IL-12 was produced by macrophages infiltrating the infected epithelium as the first response cytokine and its production at the site of infection may direct an early immune defense to alleviate the severity of infection.

Keywords: Influenza A virus; interleukin 12; cytokines; macrophages; mice; pneumonia
Year: 2009, Volume: 53, Issue: 4 Page From: 233, Page To: 240
doi:10.4149/av_2009_04_233


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