Home General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.3, p.260-265, 2009

Journal info

Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.28, No.3, p.260-265, 2009

Title: Effects of static magnetic field exposure on antioxidative enzymes activity and DNA in rat brain
Author: Salem Amara, Thierry Douki, Catherine Gare, Alain Favier, Mohsen Sakly, Khémais B. Rhouma and Hafedh Abdelmelek

Abstract: The present study was undertaken in order to investigate the effects of static magnetic field (SMF) exposure on the antioxidative enzymes activity, malondialdehyde (MDA) concentration and DNA oxidation in male rat brain. The exposure of rats to SMF (128 mT, 1 h/day during 30 consecutive days) decreased the glutathione peroxidase (GPx; –39%, p < 0.05), CuZn superoxide dismutase (CuZn-SOD; –35%, p < 0.05) and catalase (–59%, p < 0.05) activities in frontal cortex. The same treatment decreased the CuZn-SOD (–51%, p < 0.05) and Mn-SOD (–13%, p < 0.05) activities in hippocampus. However, the glutathione levels remained unchanged in the both brain structures. In the hippocampus, SMF exposure increased MDA concentration (+32%, p < 0.05). Interestingly, exposed-rats to SMF displayed a significant increase of metallothioneins level in frontal cortex (+100%, p < 0.05), while the 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo) concentration remained unaffected, indicating the absence of DNA oxidation.
Our results indicated that sub-chronic exposure to SMF induced oxidative stress in rat hippocampus and frontal cortex. Metallothionein induction protected probably DNA against oxidative damage.

Keywords: Static magnetic field — Frontal cortex — Hippocampus — Oxidative stress — Rat
Year: 2009, Volume: 28, Issue: 3 Page From: 260, Page To: 265

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.