Home 
CONTACT General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.4, p.363–370, 2009
CONTACT General Physiology and Biophysics 2009 General Physiology and Biophysics Vol.28, No.4, p.363–370, 2009
Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.28, No.4, p.363–370, 2009 |
||
| Title: Vitamin D3 affects expression of thyroid hormone receptor alpha and deiodinase activity in liver of MNU-treated Sprague-Dawley rats | ||
| Author: Dana Macejová, Slavomíra Ondková and Július Brtko | ||
| Abstract: 1α,25-dihydroxyvitamin D3 and its analogue, Seocalcitol (EB1089), are able to reverse or slow the process of carcinogenesis in experimental models and cell cultures. The aim of this study was to investigate the effect of administration vitamin D or Seocalcitol to female Sprague-Dawley rats with 1-methyl-1-nitrosourea (MNU)-induced carcinogenesis of mammary glands on binding characteristics and mRNA levels of thyroid hormone receptors (TRs). Chemopreventive administration of vitamin D caused significant reduction of animal body weight. The expression of TRα mRNA was significantly higher in liver of animals treated with vitamin D after detection of first tumour. In our experiment, administration of vitamin D or Seocalcitol significantly reduced KA (group MNU+Seo; MNU+D) and increased Bmax (group MNU+Seo) of thyroid receptors in liver when compared to healthy animals. We show that the activity type I 5’-deiodinase was significantly decreased in livers of animals treated with vitamin D. The data from our in vivo experiment has clearly shown, for the first time, that vitamin D but not Seocalcitol i) may affect the body weight of animals, ii) can cause an increase in the expression of TRα in rat liver, remaining the functionality of the TRs unaffected, and iii) is responsible for type I iodothyronine 5’-deiodinase activity decrease in rat liver, remaining the expression of the enzyme unaffected. |
||
| Keywords: Vitamin D — Seocalcitol — Iodothyronine 5’-deiodinase — Nuclear receptor — MNU — Liver | ||
| Year: 2009, Volume: 28, Issue: 4 | Page From: 363, Page To: 370 | |
| doi:10.4149/gpb_2009_04_363 |
||
|
|
 download file |
|