Home Endocrine Regulations 2010 Endocrine Regulations Vol.44, No.1, p.17-24, 2010

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Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.44, No.1, p.17-24, 2010

Title: Plasma levels of ICAM-1 and circulating endothelial cells are elevated in unstable types 1 and 2 diabetes
Author: M. El_Amine, S. Sohawon, L. Lagneau, N. Gaham, G. Berkenboom, P. Mols, S. O. Noordally

Abstract: Objective. To investigate the expression and release of vascular cell-adhesion molecule (VCAM)-1, intercellular adhesion molecule (ICAM)-1, endothelial leukocyte adhesion molecule (ELAM)-1 and von Willebrand factor (vWF), as well as circulating endothelial cells (CEC) and circulating endothelial progenitor cells (CEPC), as markers of endothelial dysfunction in uncontrolled, well controlled types 1 and 2 diabetic patients and non diabetic patients.
Methods. In this observational trans section study, soluble adhesion molecules concentrations were measured by enzyme linked immunosorbent assays and flow cytometry to detect circulating cells in 49 patients, stratified in 3 groups: G1: uncontrolled types 1 and 2 diabetic patients (n=16); G2: well controlled diabetic (types 1 and 2) patients (n=13); and G3: non diabetic patients (n=20), of whom a blood sample was obtained on admission.
Results. ICAM-1 increased significantly in uncontrolled versus well controlled and non diabetic patients (721 vs. 702.45 vs. 473.46 ng/ml, p = 0.016). In unstable diabetic patients, CEC were higher than in the well controlled ones (7.75 vs. 4.3/ml, p = 0.386) whereas CEPC were lower in unstable diabetics (56.5 vs. 72/ml, p = 0.068).
Conclusions. This study showed a continuous rise in ICAM-1 and CEC levels as stable, well controlled diabetic patients shift towards decompensation. In unstable diabetic patients, the relationship between CEC and CEPC can be represented as [CEC] α 1/[CEPC].

Keywords: Vascular adhesion molecules – Circulating endothelial cells – Circulating endothelial progenitor cells – Diabetes type 1 and 2
Year: 2010, Volume: 44, Issue: 1 Page From: 17, Page To: 24
Price: 16.00 €

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