Acta Virologica Vol.54, No.1, p.75-78, 2010
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Title: Expression of microRNA-155 precursor in peripheral blood mononuclear cells from hepatitis C patients after antiviral treatment |
Author: M. Sidorkiewicz, M. Grek, B. Jozwiak, E. Majda-Stanislawska, A. Piekarska, J. Bartkowiak |
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Abstract: Chronic hepatitis caused by Hepatitis C virus (HCV) is the main source of liver cirrhosis, hepatocellular carcinoma, and extra-hepatic diseases. After treatment-induced resolution of hepatitis C, the persistence of HCV RNA in serum and peripheral blood mononuclear cells (PBMCs) is often observed. An expression of the precursor of microRNA-155 (miR-155) called BIC can be the factor responsible for a course of HCV infection. Therefore, we assessed the relationship between BIC expression and HCV RNA status in sera and PBMCs samples of 64 hepatitis C patients treated with interferon α (IFN-α) + ribavirin. High expression of BIC in PBMCs was determined in 100% of patients that harbored HCV RNA in serum and PBMCs. Further, we found that 83% of PBMCs samples were BIC-positive in a group of patients that eliminated HCV RNA only from serum. The lowest expression of BIC was found in patients that eliminated HCV RNA from both serum and PBMCs.
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Keywords: Hepatitis C virus; microRNA-155; peripheral blood mononuclear cells; BIC; antiviral treatment |
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Year: 2010, Volume: 54, Issue: 1 |
Page From: 75, Page To: 78 |
doi:10.4149/av_2010_01_75
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Price:
9.60 €
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