Home CONTACT Neoplasma 2010 Neoplasma Vol.57, No.3, p.215-221, 2010

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ISSN 0028-2685
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Neoplasma Vol.57, No.3, p.215-221, 2010

Title: Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia
Author: J. Brezinova, A. Berkova, S. Vcelikova, Z. Zemanova, S. Izakova, I. Sarova, H. Cechova, J. Tajtlova, L. Grosova, L. Lizcova, E. Malinova, M. Zemanova, E. Cmunt, J. Karban, M. Trneny, J. Schwarz, K. Michalova

Abstract: Telomere length was evaluated by terminal repeat fragment method in 66 previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to ascertain whether telomere shortening was associated with genomic aberrations, immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70 expression, and telomerase activity. Chromosomal aberrations were present in peripheral blood cells of 73% patients (48/66), no difference in telomere length between patients with good and intermediate prognosis according to cytogenetics was found. Association between telomere length and IgVH mutational status, ZAP-70 and CD38 expression was proved as significantly shorter telomeres in patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11 patients out of 21 examined, correlation between telomere length and telomerase activity was found (p=0.05). Telomere length and telomerase activity in combination with other prognostic parameters complete the risk profile of B-CLL patients and might serve for an easy decision on optimal treatment strategy.

Keywords: B-chronic lymphocytic leukemia, telomere length, telomerase activity, chromosomal aberrations, prognosis
Year: 2010, Volume: 57, Issue: 3 Page From: 215, Page To: 221
doi:10.4149/neo_2010_03_215
Price: 16.80 €






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