Home Neoplasma 2010 Neoplasma Vol.57, No.3, p.222-227, 2010

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Neoplasma Vol.57, No.3, p.222-227, 2010

Title: Nuclear translocation of telomerase reverse transcriptase: a critical process in chemical induced hepatocellular carcinogenesis
Author: Y. Chen, Q. Kong

Abstract: Telomerase, a ribonuclearprotein complex, functions not only in cancer development but also in apoptosis, and senescence. As a catalytic subunit of telomerase, telomerase reverse transcriptase (TERT) has been confirmed to regulate telomerase activity in a rate-limiting manner. Although a lot of work has been done, the dynamic state of TERT protein and the relationship with telomerase have not been delineated systematically in cancer development. The purpose of this study was to do such an exploration. To investigate the role of TERT in the in vivo carcinogenesis, we performed immunofluorescence and Western blot analysis, respectively, to detect the alteration of TERT status as well as telomeric repeat amplification protocol (TRAP) assay to detect telomerase activity in diethyl nitrosoamine (DENA) induced rat hepatocellular carcinoma (HCC). The course of cancer development was divided into three main stages, which were inflammation ( 

Keywords: hepatocellular carcinoma; telomerase; telomerase reverse transcriptase; TERT translocation
Year: 2010, Volume: 57, Issue: 3 Page From: 222, Page To: 227
doi:10.4149/neo_2010_03_222
Price: 12.60 €






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