Home CONTACT Neoplasma 2010 Neoplasma Vol.57, No.3, p.234-240, 2010

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.57, No.3, p.234-240, 2010

Title: Increased 18F-FDG uptake and expression of Glut1 in the EMT transformed breast cancer cells induced by TGF-β
Author: W. Li, Z. Wei, Y. Liu, H. Li, R. Ren, Y. Tang

Abstract: As carcinomas progress, the tumors may lose epithelial morphology and acquire mesenchymal characteristics typically called epithelial-mesenchymal transition (EMT), which is commonly associated with increased cell migration, enables cells to dissociate from their original tissue and form metastasis in distant organs. In addition to molecular and morphologic changes, the EMT transformed cells also showed the change of sensitivity to chemotherapeutics. In order to detect the EMT transition in vivo clinically, we detected the change of metabolism of MCF-7 cells after being induced by TGF-β to form EMT condition by MTT and 18F-FDG uptake.

Keywords: EMT; TGF-β; breast cancer; metabolism; 18F-FDG
Year: 2010, Volume: 57, Issue: 3 Page From: 234, Page To: 240
doi:10.4149/neo_2010_03_234
Price: 16.80 €






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