Home CONTACT Neoplasma 2010 Neoplasma Vol.57, No.4, p.365-368, 2010

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.57, No.4, p.365-368, 2010

Title: Deleted in Breast Cancer 1 (DBC1) is a dynamically regulated protein
Author: J. E. Kim, S. Sung

Abstract: Deleted in breast cancer 1 (DBC1, KIAA1967, p30 DBC) is a novel protein that has been suggested to be a critical regulator of tumorigenesis. DBC1 modulates the activities of various proteins, including SIRT1, ERα, RARα, and AR. The functions of DBC1 with target molecules have been investigated, but little is known of its molecular characteristics. We found that DBC1 is homo-oligomerized and exhibits a dynamic expression pattern during cell cycle. In addition, DBC1 expression is higher in lung cancer cells than in normal lung fibroblasts and the protein recognized by anti-DBC1 antibodies in normal cells differs from that in lung and breast cancer cells. Further examination of the oligomerization and the dynamic expression of DBC1 during the cell cycle will help us to understand the mechanisms of DBC1 function. Moreover, the elucidation about differential expression of DBC1 between normal cells and cancer cells will aid the development of DBC1 as a diagnostic marker for cancers.

Keywords: DBC1, SIRT1, tumor suppressor, tumor promoter, cancer
Year: 2010, Volume: 57, Issue: 4 Page From: 365, Page To: 368
doi:10.4149/neo_2010_04_365
Price: 9.60 €






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