Acta Virologica Vol.54, No.2, p.119-124, 2010

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.54, No.2, p.119-124, 2010
Title: Avian leukosis virus p27 inhibits tumor necrosis factor α expression in RAW264.7 macrophages after stimulation with lipopolysaccharide
Author: P. Pang, F. Y. Chen, J. Tang, L. F. Ma, J. C. Wang, S. J. Zheng

Abstract: Avian leukosis is a widely distributed disease caused by Avian leukosis virus (ALV). ALV p27 is a capsid protein and group specific antigen, whose role in host immune response is poorly understood. To explore ALV p27, we developed a RAW264.7 macrophage cell line stably expressing p27-GFP fusion protein. The cells of this line and control cell line expressing GFP protein only were compared in production of tumor necrosis factor α (TNF-α), interleukins IL-1β, IL-6, IL-12, and in proliferative activity stimulated by the lipopolysaccharide (LPS). It was found that the ALV p27 expression markedly reduced the production of TNF-α, but did not affect the production of IL-1β, IL-6, and 12, and cell proliferative activity. These results demonstrate that ALV p27 specifically inhibits TNF-α expression in the macrophages stimulated by LPS, suggesting a possible contribution of ALV p27 to immunosuppression detected in ALV-infected hosts.

Keywords: Avian leukosis virus; p27; tumor necrosis factor α; interleukins; macrophages; lipopolysaccharide

Year: 2010, Volume: 54, Issue: 2	Page From: 119, Page To: 124
doi:10.4149/av_2010_02_119
Price: 14.40 €

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