Home FOR AUTHORS Neoplasma 2010 Neoplasma Vol.57, No.6, p.512-521, 2010

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Neoplasma Vol.57, No.6, p.512-521, 2010

Title: CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients
Author: A. O. ADA, S. C.KUNAK, F. HANCER, S. BILGEN, S. H. SUZEN, S. ALPAR, M. GULHAN, B. KURT, M. ISCAN

Abstract: Several polymorphisms in cytochrome P-450s (CYP)s and Glutathione S-transferases (GST)s have been reported to be associated with survival rates of patients with non-small cell lung cancer (NSCLC) but the studies in this regard are scarce and the results are contradictory. In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Ala114Val) and GSTT1 polymorphisms were determined in 138 patients with advanced NSCLC to evaluate their role in survival. Of the studied CYP and GST polymorphisms only GSTP1 exon 6 variant significantly altered (improved) the survival compared to wild type (p=0.036) with median survival of 22.2 months and 16.1 months, respectively. Multivariate analysis also revealed a significant reduction of adjusted hazard ratio of death associated only with the GSTP1 exon 6 variant genotype of 0.45 (95% confidence interval (95% CI), 0.23-0.89, p=0.022). These results show that the GSTP1 exon 6 variant genotype is associated with improved survival in the patients with advanced NSCLC.

Keywords: Cytochrome P-450, glutathione S-transferase, non small cell lung cancer, polymorphism, survival
Year: 2010, Volume: 57, Issue: 6 Page From: 512, Page To: 521
doi:10.4149/neo_2010_06_512
Price: 24.00 €






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