Home Neoplasma 2010 Neoplasma Vol.57, No.6, p.545-551, 2010

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.57, No.6, p.545-551, 2010

Title: Prognostic role of Wnt7a expression in ovarian carcinoma patients
Author: X. L. ZHANG, C. J. PENG, J. PENG, L. Y. JIANG, X. M. NING, J. H. ZHENG


Wnt7a is a secreted glycoprotein that regulates normal cellular proliferation and differentiation as well as tumorigenesis and progression. The aim of this study was to investigate the expression and prognostic significance of Wnt7a in ovarian carcinoma. Wnt7a expression was immunohistochemically examined in normal ovaries (n=15), benign tumors (n=50) and ovarian carcinomas (n=78). The correlation of Wnt7a expression with clinicopathological parameters and survival was evaluated. Wnt7a expression was higher in ovarian carcinomas compared to normal ovaries and benign tumors (p<0.001 and p=0.001, respectively).

Wnt7a positive expression was significantly correlated with serous subtype (p<0.001), elder age (p=0.017), advanced stage (p<0.001), high grade (p=0.001), a high degree of ascitic fluid volume (p=0.015) and high CA125 expression (p=0.025). Wnt7a was found to be a significant prognostic factor in univariate and multivariate analysis.
High Wnt7a expression in ovarian cancer may be associated with poor prognosis.

Keywords: Wnt7a, expression, ovarian cancer, prognosis.
Year: 2010, Volume: 57, Issue: 6 Page From: 545, Page To: 551

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