Home FOR AUTHORS Neoplasma 2010 Neoplasma Vol.57, No.6, p.578-589, 2010

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.57, No.6, p.578-589, 2010

Title: Prognostic factors and treatment outcome in 1,516 adult patients with de novo and secondary acute myeloid leukemia in 1999–2009 in 5 hematology intensive care centers in the Czech Republic
Author: T. SZOTKOWSKI, J. MUZIK, J. VOGLOVA, V. KOZA, J. MAALOUFOVA, T. KOZAK, M. JAROSOVA, K. MICHALOVA, P. ZAK, K. STEINEROVA, J. VYDRA, M. LANSKA, B. KATRINCSAKOVA, K. SICOVA, T. PAVLIK, L. DUSEK, K. INDRAK

Abstract: Acute myeloid leukemia (AML) is a severe condition with a high mortality. When making decisions about the optimal tailor-made therapy, numerous prognostic factors are considered. The study represents a detailed analysis of the role of these factors and treatment outcomes based on a long-term follow-up of patients treated in 5 hematology intensive care centers in the Czech Republic.
The studied group comprised 1,188 patients with de novo AML and 328 patients with secondary AML. The latter were significantly older, had more unfavorable cytogenetic changes and less frequently received curative therapy. Curatively treated patients achieved fewer complete remissions and relapsed more often than those with de novo AML. Patients with secondary AML had lower rates of allogeneic transplantation as part of consolidation therapy and a significantly shorter median overall survival. A lower proportion of the patients were alive at the time of analysis.
However, the treatment outcome of de novo AML patients is not satisfactory, the only exception being those with acute promyelocytic leukemia. The analysis, which did not evaluate the intention-to-treat criteria and was without randomization, found allogeneic stem cell transplantation to be the most effective modality of consolidation therapy in both groups of patients.

Keywords: Acute myeloid leukemia, prognostic factors, consolidation, stem cell transplantation, treatment outcome, registry
Year: 2010, Volume: 57, Issue: 6 Page From: 578, Page To: 589
doi:10.4149/neo_2010_06_578
Price: 28.80 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.