Neoplasma Vol.57, No.6, p.590-593, 2010
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| Title: Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes |
| Author: F. ROTONDO, S. SHARMA, B. W. SCHEITHAUER, E. HORVATH, L. V. SYRO, M. CUSIMANO, F. NASSIRI, G. M. YOUSEF, K. KOVACS |
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Abstract: Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis.
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| Keywords: immunohistochemistry, endoglin, CD34, microvascular density, angiogenesis, pituitary |
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| Year: 2010, Volume: 57, Issue: 6 |
Page From: 590, Page To: 593 |
doi:10.4149/neo_2010_06_590
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