Home Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.247-253, 2010

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.54, No.4, p.247-253, 2010

Title: Variation of Human papillomavirus 16 in cervical and lung cancers in Sichuan, China
Author: J. ZHANG, T. WANG, M. HAN, Z. H. YANG, L. X. LIU, Y. CHEN, L. ZHANG, H. Z. HU, M. R. XI

Abstract: Although the crucial role of human papillomaviruses (HPVs), especially HPV-16 in various cancers has been confirmed, the variation of HPV-16 among different cancers have not been investigated in a specific geographic location. In order to elucidate whether similar HPV-16 variants are involved in different kinds of cancers in the same geographic location, the analysis of sequence variants of E6 and E7 oncogenes and L1 gene of HPV-16 in cervical and lung cancers in Sichuan, China, was carried out. Tissue samples from 122 cervical cancers, 104 lung cancers, and 138 controls were subjected to RT-PCR or PCR, sequencing, and sequence analysis. The infection rates of HPV-16 in cervical, lung cancers, and non-malignant controls were 68.9%, 17.3%, and 37.0%, respectively. Asian prototype variants prevailed in cervical and lung cancers, while European prototype variants in non-malignant controls. In comparison to the lung cancer, cervical cancer showed a much higher diversity of HPV-16 oncogenes. These results indicate that in Sichuan, China, Asian prototype variants of HPV-16 are more pathogenic than their European counterparts.

Keywords: Human papillomavirus 16; cervical cancer; lung cancer; E6, E7, L1 genes; sequence variation
Year: 2010, Volume: 54, Issue: 4 Page From: 247, Page To: 253
doi:10.4149/av_2010_04_247


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