Home 
Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.247-253, 2010
Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.247-253, 2010
Journal info
Aims and Scope |
||
Select Journal
Journals
Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.54, No.4, p.247-253, 2010 |
||
| Title: Variation of Human papillomavirus 16 in cervical and lung cancers in Sichuan, China | ||
| Author: J. ZHANG, T. WANG, M. HAN, Z. H. YANG, L. X. LIU, Y. CHEN, L. ZHANG, H. Z. HU, M. R. XI | ||
| Abstract: Although the crucial role of human papillomaviruses (HPVs), especially HPV-16 in various cancers has been confirmed, the variation of HPV-16 among different cancers have not been investigated in a specific geographic location. In order to elucidate whether similar HPV-16 variants are involved in different kinds of cancers in the same geographic location, the analysis of sequence variants of E6 and E7 oncogenes and L1 gene of HPV-16 in cervical and lung cancers in Sichuan, China, was carried out. Tissue samples from 122 cervical cancers, 104 lung cancers, and 138 controls were subjected to RT-PCR or PCR, sequencing, and sequence analysis. The infection rates of HPV-16 in cervical, lung cancers, and non-malignant controls were 68.9%, 17.3%, and 37.0%, respectively. Asian prototype variants prevailed in cervical and lung cancers, while European prototype variants in non-malignant controls. In comparison to the lung cancer, cervical cancer showed a much higher diversity of HPV-16 oncogenes. These results indicate that in Sichuan, China, Asian prototype variants of HPV-16 are more pathogenic than their European counterparts. |
||
| Keywords: Human papillomavirus 16; cervical cancer; lung cancer; E6, E7, L1 genes; sequence variation | ||
| Year: 2010, Volume: 54, Issue: 4 | Page From: 247, Page To: 253 | |
| doi:10.4149/av_2010_04_247 |
||
|
Price:
16.80 €
|
||
|
|
||