Acta Virologica Vol.54, No.4, p.269-274, 2010

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ISSN 0001-723X
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Acta Virologica Vol.54, No.4, p.269-274, 2010
Title: A recombinant rabies virus expressing luciferase
Author: H. LIANG, Y. TAN, C. DUN, X. GUO

Abstract: A recombinant Rabies virus (RV) expressing firefly luciferase (rRV-luc) was generated by an improved reverse genetics system. Its biological properties were compared with those of the parental RV. The rRV-luc grew in BHK-21 cells similarly to RV, but its virulence for mice was weaker as shown by the lower infectious titers in brain. Rising infectious titers of rRV-luc during its passaging in BHK-21 cells indicated a virus adaptation, while the luciferase (luc) expression was stable. These results suggest that the recombinant RV carrying luc gene might prove a useful tool for further analysis of pathogenesis of RV in small animal models.

Keywords: Rabies virus; luciferase; reverse genetic

Year: 2010, Volume: 54, Issue: 4	Page From: 269, Page To: 274
doi:10.4149/av_2010_04_269
Price: 14.40 €

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