Home CONTACT Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.269-274, 2010

Journal info


Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Aims and Scope
Abstracted and Indexed

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.54, No.4, p.269-274, 2010

Title: A recombinant rabies virus expressing luciferase
Author: H. LIANG, Y. TAN, C. DUN, X. GUO

Abstract: A recombinant Rabies virus (RV) expressing firefly luciferase (rRV-luc) was generated by an improved reverse genetics system. Its biological properties were compared with those of the parental RV. The rRV-luc grew in BHK-21 cells similarly to RV, but its virulence for mice was weaker as shown by the lower infectious titers in brain. Rising infectious titers of rRV-luc during its passaging in BHK-21 cells indicated a virus adaptation, while the luciferase (luc) expression was stable. These results suggest that the recombinant RV carrying luc gene might prove a useful tool for further analysis of pathogenesis of RV in small animal models.

Keywords: Rabies virus; luciferase; reverse genetic
Year: 2010, Volume: 54, Issue: 4 Page From: 269, Page To: 274
doi:10.4149/av_2010_04_269
Price: 14.40 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.