Home Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.293-296, 2010

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.54, No.4, p.293-296, 2010

Title: Immune responses of mice to prime-boost vaccination with the recombinant DNA and Fowlpox virus both expressing HIV-2 Gag-gp105
Author: Y. SONG, L. S. ZHANG, H. WANG, H. JIN, CH. LI, N. JIN

Abstract:  Human immunodeficiency viruses 1 and 2 (HIV-1, 2) present a public health problem for which there is neither an effective antiviral therapy nor a preventive vaccine. In this study, the immune responses of mice to prime-boost vaccination with the recombinant DNA (rDNA) and recombinant Fowlpox virus (rFPV) both expressing HIV-2 Gag-gp105 chimeric protein, were compared to those elicited by each vector alone. Mice primed with the rDNA and boosted with the rFPV showed HIV-2-specific antibody levels, splenic CD4+ and CD8+ T-lymphocyte numbers, and Gag-gp105-specific cytotoxic T-lymphocytes (CTL) activity increased by 20–30% as compared with those elicited by these vaccines alone. These findings suggested that the prime-boost strategy combining rDNA and rFPV elicited significant Gag-gp105 – specific cellular and humoral immune responses, thus supporting this novel approach to the immunization against HIV infections.

Keywords: HIV-2; DNA vaccine; Fowlpox virus; Gag-gp105 chimeric protein; prime-boost
Year: 2010, Volume: 54, Issue: 4 Page From: 293, Page To: 296
doi:10.4149/av_2010_04_293


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