Home Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.307-310, 2010

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.54, No.4, p.307-310, 2010

Title: Integrity of foot-and-mouth disease virions bound to the cells
Author: J. YI, CH. LIU

Abstract: In this study, we examined the integrity of Foot-and-mouth disease virus (FMDV) particles during their binding to the surface of BHK-21 cells under physiological condition. For monitoring of the virus integrity we used blocking of the endocytosis with dynasore and cytochalasin D followed by RT-PCR for viral protein VP1 and the resistance of FMDV to the treatment of RNase A. Our results showed that integrin binding to VP1 did not cause a substantial conformational change in the viral capsid. Furthermore, treatment with RNase A showed no effect on the infectivity of intact as well as cell-bound virions. Our findings confirmed that FMDV entered the host cells in the form of intact virions.

Keywords: Foot-and-mouth disease virus; virus-cell binding; RNase A; RT-PCR; VP1 protein
Year: 2010, Volume: 54, Issue: 4 Page From: 307, Page To: 310
doi:10.4149/av_2010_04_307


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