Home Acta Virologica 2010 Acta Virologica Vol.54, No.4, p.311-313, 2010

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.54, No.4, p.311-313, 2010

Title: Effect of the route of foot-and-mouth disease virus inftection of piglets on the course of disease
Author: D. LI, X. W. BAI, P. SUN, Y. F. FU, B. X. XIE, Z. J. LU, Y. L. CHEN, W. J. CAO, Z. X. LIU

Abstract: Three different routes of Foot-and-mouth disease virus (FMDV) infection of piglets, namely intranasal (i.n.) through drops, intradermal (i.d.) into the foot, and intramuscular (i.m.) were compared regarding the onset and severity of the disease. The results showed that the i.d. injection of the virus resulted in the fastest onset of the disease. The i.m. injection led to a delayed onset, but the final effect was identical with i.d. injection. Moreover, the i.m. injection was simpler to perform and easier to evaluate. Therefore, the i.m. injection of piglets is recommended as the optimal infection route for evaluation of the FMDV vaccine potency.

Keywords: Foot-and-mouth disease virus; challenge routes; intranasal drops; intradermal injection; intramuscular injection; pig
Year: 2010, Volume: 54, Issue: 4 Page From: 311, Page To: 313
doi:10.4149/av_2010_04_311


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