Home Endocrine Regulations 2011 Endocrine Regulations Vol.45, No.1, p.29-36, 2011

Journal info

Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Endocrine Regulations Vol.45, No.1, p.29-36, 2011

Title: Prostatic assessment in rats after bilateral orchidectomy and calcitonin treatment
Author: A. R. Al-Shahat, M. A. Shaikh, R. A. Elmansy, K. Shehzad, Z. A. Kaimkhani

Abstract: Objective. Bilateral orchidectomy is widely used as a treatment in patients with metastatic prostatic cancer, but post-orchidectomy osteoporosis is a common sequel which is commonly treated by postoperative calcitonin injection. Since the increase in the invasiveness of malignant prostatic cells has been attributed to the use of calcitonin, this study was aimed to elucidate the effect of calcitonin on the structure of the prostate after orchidectomy in rats used as mammalian model.
Methods. A total of 84 adult male albino rats were divided into three groups: Group 1 (12 control rats); Group 2 (36 rats subjected to bilateral orchidectomy); Group 3 (36 rats subjected to bilateral orchidectomy and injected subcutaneously with calcitonin (5 µg/kg) every other day. Six animals of Group 2 and 3 were sacrificed two, four, eight, sixteen and twenty four weeks after orchidectomy. The prostates were removed and processed for morphometric measurements by using the image analyzer computer system.
Results. The present study demonstrated a decrease in the height and apoptosis of the epithelial lining of the prostatic acini. There was also an increase in the interacinar fibromuscular stroma. However, calcitonin administration following orchidectomy limited these changes.
Conclusion. Bilateral orchidectomy produced time related atrophic changes in the prostate, while a simultaneous administration of calcitonin inhibits the development of these atrophic changes.

Keywords: prostate, prostatic carcinoma, calcitonin, prostatic acini, osteoporosis, prostatic atrophy
Year: 2011, Volume: 45, Issue: 1 Page From: 29, Page To: 36
Price: 16.00 €

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.