Home Endocrine Regulations 2011 Endocrine Regulations Vol.45, No.1, p.49-60, 2011

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Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.45, No.1, p.49-60, 2011

Title: Polymeric nanoparticles - targeted drug delivery systems for treatment of CNS disorders and their possible endocrine disrupting activities
Author: E. Rollerova, S. Scsukova, J. Jurcovicova, A. Mlynarcikova, E. Szabova, J. Kovriznych, D. Zeljenkova

Abstract: Drug delivery to the central nervous system (CNS) represents one of the most priority challenges in research and development of pharmaceutical nanotechnology products. Among the various non-invasive approaches for CNS delivery, nanoparticle carriers and particularly polymeric nanoparticles (PNs) seem to be one of the most interesting. This review deals with PNs as CNS drug delivery systems and their potential endocrine disrupting properties. Possible interference with the development of neuroendocrine-reproductive system is considered. Special regard is being paid to potential mechanisms of PNs toxicity. Necessity to investigate the toxicity of nanomaterials and their impact on human health are discussed.

Keywords: endocrine disruption, nanomaterials, polymeric nanoparticles, nanotoxicology, reproduction, KiSS-1 system, polyethylene glycol, review
Year: 2011, Volume: 45, Issue: 1 Page From: 49, Page To: 60
Price: 24.00 €

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