Home General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.1, p.28–33, 2011

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.30, No.1, p.28–33, 2011

Title: Contribution of Nav1.1 to cellular synchronization and automaticity in spontaneous beating cultured neonatal rat ventricular cells
Author: Haruko Masumiya

Abstract: Two factors of cell coupling influence cellular synchronization and automaticity: gap junction coupling and ion channels activity. However, the role of Na+ channel isoforms underlying cell-to-cell interaction and cellular automaticity is not well understood. To address these questions, we studied mRNA expression of Na+ channel isoforms and the effects of TTX on spontaneously beating cultured ventricle cells. Using RT-PCR technique we demonstrated the presence of Nav1.1 and Nav1.5 channels. The reduction of Nav1.1 channel activity disturbed cell-to-cell interaction and changed beating rates. Thus, Nav1.1 channel is involved in cellular synchronization and automaticity.

Keywords: Na+ channel — Isoforms — Cultured ventricular cells — Synchronization — Rhythm generation
Year: 2011, Volume: 30, Issue: 1 Page From: 28, Page To: 33

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