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General Physiology and Biophysics Vol.30, No.1, p.28–33, 2011 |
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Title: Contribution of Nav1.1 to cellular synchronization and automaticity in spontaneous beating cultured neonatal rat ventricular cells | ||
Author: Haruko Masumiya | ||
Abstract: Two factors of cell coupling influence cellular synchronization and automaticity: gap junction coupling and ion channels activity. However, the role of Na+ channel isoforms underlying cell-to-cell interaction and cellular automaticity is not well understood. To address these questions, we studied mRNA expression of Na+ channel isoforms and the effects of TTX on spontaneously beating cultured ventricle cells. Using RT-PCR technique we demonstrated the presence of Nav1.1 and Nav1.5 channels. The reduction of Nav1.1 channel activity disturbed cell-to-cell interaction and changed beating rates. Thus, Nav1.1 channel is involved in cellular synchronization and automaticity. |
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Keywords: Na+ channel — Isoforms — Cultured ventricular cells — Synchronization — Rhythm generation | ||
Year: 2011, Volume: 30, Issue: 1 | Page From: 28, Page To: 33 | |
doi:10.4149/gpb_2011_01_28 |
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2011 Special Issue |