General Physiology and Biophysics Vol.30, No.1, p.34

General Physiology and Biophysics Vol.30, No.1, p.34–44, 2011

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.30, No.1, p.34–44, 2011
Title: Role of glucagon-like peptide-1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts
Author: Ghinwa M. Barakat, Nuha Nuwayri-Salti, Lina N. Kadi, Khalil M. Bitar, Wael A. Al-Jaroud, Anwar B. Bikhazi

Abstract: Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from intestinal L cells upon nutrients ingestion, and is currently used for treating diabetes mellitus. It plays an important role in receptor modulation and cross talk with insulin at the coronary endothelium (CE) and cardiomyocytes (CM) in diabetic type 1 rat heart model. We studied the effects of insulin, GLP-1 analogues (exendin-4), and dipeptidyl peptidase-IV (DPP-IV) inhibitor on GLP-1 cardiac receptor modulation. The binding affinity of GLP-1 to its receptor on CE and CM was calculated using a rat heart perfusion model with [125I]-GLP-1(7-36). Tissue samples from the heart were used for immunostaining and Western blot analyses. GLP-1 systemic blood levels were measured using ELISA. GLP-1 binding affinity (τ) increased on the CE (0.33 ± 0.01 vs. 0.25 ± 0.01 min; p

Keywords: Binding affinity — Dipeptidyl peptidase-IV inhibitor — Dissociation constant — Exendin-4 — Glucagon-like peptide-1

Year: 2011, Volume: 30, Issue: 1	Page From: 34, Page To: 44
doi:10.4149/gpb_2011_01_34
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