General Physiology and Biophysics Vol.30, No.1, p.100

General Physiology and Biophysics Vol.30, No.1, p.100–105, 2011

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.30, No.1, p.100–105, 2011
Title: Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques
Author: Kee-Hyun Choi, Chiman Song, Chan S. Cheong, Hyewhon Rhim

Abstract: T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Cav3.1 T-type channels using automated patch-clamp. The IC50 values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels.

Keywords: T-type calcium channel — Cav3.1 — Automated patch-clamp — Drug discovery

Year: 2011, Volume: 30, Issue: 1	Page From: 100, Page To: 105
doi:10.4149/gpb_2011_01_100
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