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General Physiology and Biophysics Vol.30, No.1, p.100–105, 2011 |
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Title: Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques | ||
Author: Kee-Hyun Choi, Chiman Song, Chan S. Cheong, Hyewhon Rhim | ||
Abstract: T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Cav3.1 T-type channels using automated patch-clamp. The IC50 values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels. |
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Keywords: T-type calcium channel — Cav3.1 — Automated patch-clamp — Drug discovery | ||
Year: 2011, Volume: 30, Issue: 1 | Page From: 100, Page To: 105 | |
doi:10.4149/gpb_2011_01_100 |
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2011 Special Issue |