Home General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.1, p.106–109, 2011

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.30, No.1, p.106–109, 2011

Title: Evaluation of uridine 5’-eicosylphosphate as a stimulant of cyclic AMP-dependent cellular function
Author: Masahiro Yutani, Akira Ogita, Ken-ichi Fujita, Yoshinosuke Usuki, Toshio Tanaka

Abstract: Sporulation of the yeast Saccharomyces cerevisiae is negatively regulated by cyclic AMP (cAMP). This microbial cell differentiation process was applied for the screening of a substance that can elevate the intracellular cAMP level. Among nucleoside 5’-alkylphosphates, uridine 5’-eicosylphosphate (UMPC20) selectively and predominantly inhibited ascospore formation of the yeast cells. We suppose the inhibitory effect of UMPC20 could indeed reflect the elevation of the cellular cAMP level.

Keywords: cAMP — Sporulation — Nucleoside 5’-alkylphosphate — Saccharomyces cerevisiae
Year: 2011, Volume: 30, Issue: 1 Page From: 106, Page To: 109

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